Nicotine can transmit its effects through contact with the skin and absorption through the mouth. When a Pixotine Nicotine Toothpick is placed in the mouth, the saliva in the mouth aids in drawing out the nicotine. The nicotine contained in the saliva then gets absorbed into the bloodstream through contact with cells. Chewing slightly on Pixotine® enhances the speed at which the nicotine is released. With proper use first effects are felt from 1 min to 15 min depending on the user and the product is designed to last from 10 minutes to 1 hour.